Weaponizing T-cell receptors through molecular engineering
نویسندگان
چکیده
منابع مشابه
Molecular nature of T-cell receptors.
The immune system is crucially involved in a number of diseascs including microbial infections, allergies, cancer, rheumatism, autoimmunity and degenerative disorders of ageing. While the Tlymphocytes play a key role in the body’s immune defence mechanism, they also act to reject grafted or transplanted tissues. The T-cells comprise only about half the population of lymphocytes; the other half,...
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The T cell antigen receptor (TCR) mediates recognition of peptide antigens bound in the groove of major histocompatibility complex (MHC) molecules. This dual recognition is mediated by the complementarity-determining residue (CDR) loops of the alpha and beta chains of a single TCR which contact exposed residues of the peptide antigen and amino acids along the MHC alpha helices. The recent descr...
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onsidering the high prevalence of severe organ failures due to the cancer, congenital anomaly, or trauma, and the consequent needs for tissue transplantation, deficiencies in tissues and organs are a huge challenge for regenerative medicine at the moment. More than 40 years have passed since the term ‘tissue engineering’ was created as a new th...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2019
ISSN: 0021-9258
DOI: 10.1074/jbc.h119.008479